As a Full Stack Developer, you're no stranger to Node.js, one of the most popular choices for building scalable server-side applications. Dependencies are libraries or packages required for your application to function correctly, but they can also cause problems like version conflicts and security risks. To manage dependencies effectively, follow these best practices: use a package manager (like npm), specify dependency versions in `package.json`, distinguish between development and production dependencies, and monitor dependency security with tools like Snyk or Dependabot.